Course Information
SemesterCourse Unit CodeCourse Unit TitleL+PCreditNumber of ECTS Credits
8PHYS454MOLECULAR BIOPHYSICS II3+036

Course Details
Language of Instruction English
Level of Course Unit First Cycle
Department / Program PHYSICS
Mode of Delivery Face to Face
Type of Course Unit Elective
Objectives of the Course This is an elective course for the upper-level undergraduate students. Molecular Biophysics as a promising interdisciplinary field combines the laws and concepts of physics, biology, chemistry, biochemistry, medicine and engineering. This course offers a comprehensive introduction to the molecular physics of biological systems at the molecular and subcellular level with an emphasis on the electrical and dynamical behavior. Fundamental theories in biophysics and their applications with examples will be provided in this course as well. Thus, students will gain an understanding of the general importance and broad applicability of biophysical principles to biological problems. This may help to physicists to select a research project from the multidisciplinary fields. Since case studies from the recent scientific literatures will be given in lectures, the students will gain the practice in reading and interpreting the primary literature in the field as well.
Course Content A brief introduction to structure and functions of biological macromolecules; Forces and interactions in aqueous solutions; Molecular mechanisms of interactions in biological macromolecules; Enzyme reactions and kinetics; Membrane dynamics and membrane proteins, ion channels; Electrophysiology; Bioelectricity; Gene expression and regulation; microRNAs; Principles and basic concepts of biophysical experimental methods (absorption, dichroism, fluorescence, X-ray diffraction and others; Optical biosensors, optical spectroscopy; Case studies from recent literatures.
Course Methods and Techniques
Prerequisites and co-requisities None
Course Coordinator None
Name of Lecturers Instructor Dr. GÜNNUR GÜLER
Assistants None
Work Placement(s) No

Recommended or Required Reading
Resources
Molecular and Cellular Biophysics (Meyer B. Jackson, Cambridge Univ. Press 2010) Fundamentals of Biophysics (Andrey B. Rubin, Wiley, 2014, ISBN: 978-1-118-84275-1) Biochemistry (RH. Abeles and PA. Frey; Jones and Bartlett Series in Biology, 1992) Physical Chemistry for the Life Sciences (PW Atkins and J. Paula, Oxford Univ. Press, 2011) Relevant materials (research reviews and articles) will be provided to students.

Course Category

Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"

Assessment Methods and Criteria
In-Term Studies Quantity Percentage
Midterm exams 0 % 0
Quizzes 0 % 0
Homeworks 0 % 0
Other activities 0 % 0
Laboratory works 0 % 0
Projects 0 % 0
Final examination 0 % 0
Total
0
% 0

ECTS Allocated Based on Student Workload
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Course Learning Outcomes: Upon the successful completion of this course, students will be able to:
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Weekly Detailed Course Contents
WeekTopicsStudy MaterialsMaterials
1 Biological macromolecules: conformations, structure and functions of proteins, nucleic acids (DNA, RNA)
2 The forces determining the protein and nucleic acid structure; interactions in biomolecules
3 Use of pymol software to investigate the structure of biological macromolecules
4 Molecular mechanisms of drug/ligand interactions, nucleic acid-protein interactions
5 Molecular models of enzyme mechanisms, Enzyme reactions and kinetics
6 Membrane dynamics and membrane proteins
7 Electrophysiology
8 Ion permeation and membrane potential, ion channels
9 Fundamentals of bioelectricity of the mammalian nervous system and other excitable tissues
10 The nature of gene expression and regulation; microRNAs
11 Principles and basic concepts of biophysical experimental methods I: absorption, linear and circular dichroism, fluorescence
12 Optical biosensors, optical spectroscopy
13 Principles and basic concepts of biophysical experimental methods II: X-ray crystallography, diffraction and others
14 Case studies on the application of biophysical techniques to biological macromolecules, cells and tissues from recent literatures.


Contribution of Learning Outcomes to Programme Outcomes
P1 P2 P3 P4 P5 P6 P7 P8 P9 P10

Contribution: 0: Null 1:Slight 2:Moderate 3:Significant 4:Very Significant


https://obs.iyte.edu.tr/oibs/bologna/progCourseDetails.aspx?curCourse=261911&lang=en